ACTH(4–7) analog · Met-Glu-His-Phe-Pro-Gly-Pro
Semax
Cited range Intranasal literature
What it is
Semax is a synthetic fragment related to ACTH 4–7 with a Pro-Gly-Pro tail that improves stability. It has been studied for ischemic stroke, optic-nerve issues, and cognitive performance in Eastern European literature.
Benefits in plain language
What researchers and reference users usually mean when they talk about this compound. These are study themes and common claims — not a promise that it will do this in you.
- A Russian-origin ACTH fragment used there as a nootropic and neuro-protectant (often as a nasal drop).
- The everyday claim is clearer focus, a steadier mood under stress, and support after brain strain.
- Labs talk about BDNF and neurotransmitter modulation — in English: it may turn up the brain’s “growth and coping” signals.
- Nasal sting and overstimulation are the usual complaints if the dose is jumpy.
If a branded, FDA-approved product exists, that label is the only dose that is actually authorized. Research-chemical vials are a different object.
Mechanism of action
It does not act like a steroidogenic ACTH drug. Proposed mechanisms include melanocortin-receptor modulation, increased BDNF and NGF expression, and effects on monoamine systems. Intranasal delivery is used to reach CNS-relevant compartments without a large systemic ACTH effect.
Possible side effects / caveats
Nasal irritation, restlessness or overstimulation in some reports, headache, and the usual quality problem with research sprays. Not a first-line stroke therapy in US practice.
Protocol ranges
| Source tier | Amount | Cadence | Notes |
|---|---|---|---|
| Cited range | 200–600 mcg | 1–2× daily intranasal | Common secondary-source window |
| Cited higher | Up to ~1000 mcg/day | Split nasal sprays | Appears in nootropic references |