MGF

Cited range

ClassIGF-1 splice variant

Typical routes in papersLocal SC/IM in citations

Half-life contextVery short unless PEGylated

EvidencePreclinical plus community

What it is

MGF is the nickname for the IGF-1Ec splice that shows up when muscle is loaded or damaged. Unpegylated MGF is a brief local signal; PEG-MGF is the long-stay version already in this library.

Benefits in plain language

What researchers and reference users usually mean when they talk about this compound. These are study themes and common claims — not a promise that it will do this in you.

The idea is “repair the muscle you just tore up in the gym,” not raise whole-body GH all day.
Often paired in lore with IGF-1 DES or LR3 for local plus systemic.
Short half-life means timing around training is the whole game.

If a branded, FDA-approved product exists, that label is the only dose that is actually authorized. Research-chemical vials are a different object.

Mechanism of action

Alternative splice of IGF-1 induced by mechanical stress; proposed to activate satellite-cell and local repair programs.

Possible side effects / caveats

Local pain, edema, and IGF-family metabolic effects if enough goes systemic.

Protocol ranges

Source tier	Amount	Frequency / duration	Notes
Cited range	100–300 mcg	Local, around training days	Community figures
See also	PEG-MGF page	Longer-acting cousin	Different kinetics

Numbers below and above are literature or community pointers, not a treatment plan. Approved products, when they exist, follow the official label — not a research vial.