Ibutamoren (MK-677)

Cited range Not a peptide

ClassNon-peptide ghrelin mimetic

Typical routes in papersOral

Half-life context~24 hours

EvidenceClinical studies in GH deficiency / sarcopenia / recovery; not FDA-approved for anti-aging

What it is

Ibutamoren is an oral ghrelin-receptor agonist that raises GH and IGF-1 for a full day. It is in this peptide library because every stack conversation names it next to ipamorelin.

Benefits in plain language

What researchers and reference users usually mean when they talk about this compound. These are study themes and common claims — not a promise that it will do this in you.

What people want: easier GH/IGF rise without injections, better sleep depth, appetite for hardgainers.
It can raise fasting glucose and hunger a lot. That is the ghrelin tax.
Not approved as a lifestyle GH pill.

If a branded, FDA-approved product exists, that label is the only dose that is actually authorized. Research-chemical vials are a different object.

Mechanism of action

Potent GHSR agonism; once-daily oral pharmacokinetics flatten a GH/IGF elevation versus short GHRP pulses.

Possible side effects / caveats

Appetite, water, insulin resistance, numbness/tingling, rare prolactin/cortisol chatter. Not for people who already fight blood sugar.

Protocol ranges

Source tier	Amount	Frequency / duration	Notes
Cited range	10–25 mg oral	Once daily, often evening	Community + some trial doses
Trial literature	25 mg common in adult studies	Daily	Context-specific

Numbers below and above are literature or community pointers, not a treatment plan. Approved products, when they exist, follow the official label — not a research vial.