Mitochondrial-derived peptide · HNG analog often sold
Humanin
Cited range Preclinical-heavy
What it is
Humanin is a mitochondrial-derived peptide studied for cytoprotection. Catalogs often sell HNG (S14G-humanin), a more potent analog, under the same family name. Confirm the sequence on the COA.
Benefits in plain language
What researchers and reference users usually mean when they talk about this compound. These are study themes and common claims — not a promise that it will do this in you.
- A tiny mitochondrial peptide associated with cell survival and metabolic stress resistance in research.
- Aging and neuro papers are where the “protect the neuron / protect the cell” story comes from.
- Human dosing is not settled. This is a mechanism-first monograph.
If a branded, FDA-approved product exists, that label is the only dose that is actually authorized. Research-chemical vials are a different object.
Mechanism of action
Proposed interactions with FPRL1/FPR2 and intracellular partners (IGFBP-3, BAX-related pathways) in survival and metabolic stress models.
Possible side effects / caveats
Almost no systematic human safety file. Treat analog identity (humanin vs HNG vs HNGF6A) as a real dosing variable, not a footnote.
Protocol ranges
| Source tier | Amount | Frequency / duration | Notes |
|---|---|---|---|
| Cited range (HNG talk) | 1–5 mg | A few times weekly SC | Secondary sources; not a trial standard |