Copper tripeptide-1
GHK-Cu
Topical evidence stronger than injectable
What it is
GHK is a plasma tripeptide that binds copper(II). The complex has been studied for wound remodeling, antioxidant gene expression, and cosmetic dermal endpoints. It is one of the few catalog items with a serious topical literature.
Benefits in plain language
What researchers and reference users usually mean when they talk about this compound. These are study themes and common claims — not a promise that it will do this in you.
- A copper-carrying tripeptide found in human plasma. Skin and hair people know it as a remodeling signal.
- Plain-language aims: healthier-looking skin, more even tone, support for collagen chatter, and scalp/hair projects.
- Also studied around wound appearance and antioxidant / anti-inflammatory gene patterns.
- Copper content means more is not automatically better — skin irritation and copper load are real limits.
If a branded, FDA-approved product exists, that label is the only dose that is actually authorized. Research-chemical vials are a different object.
Mechanism of action
Proposed actions: copper delivery to enzymes such as lysyl oxidase, shifts in TGF-β and metalloproteinase balance, and broad transcriptional effects Pickart and others documented in skin models. Anti-inflammatory and hair-follicle research exists but is less standardized than wrinkle/repair cosmetics.
Possible side effects / caveats
Topical: staining, irritation, or copper sensitivity. Injectable research use can cause blue-green local color and injection-site reactions. Copper load matters if someone stacks multiple copper products.
Protocol ranges
| Source tier | Amount | Cadence | Notes |
|---|---|---|---|
| Topical literature / cosmetic | Often 0.05–1% in finished formulas | Daily application | Best-supported use pattern |
| Cited injectable | 1–2 mg | Daily or 3×/week SC | Secondary-source range; not a labeled drug dose |